Pubs and CV – Alexa Sadier, PhD

PUBLICATIONS

*: equal contributions

Preprint/in prep

Published

26. Grossnickle, D. M., Sadier, A., Patterson, E., Cortés-Viruet, N. N., Jiménez-Rivera, S. M., Sears, K. E., & Santana, S. E. (2024). The hierarchical radiation of phyllostomid bats as revealed by adaptive molar morphology. Current Biology. https://doi.org/10.1016/j.cub.2024.02.027

25. Anthwal, N., Hall, R. P., de la Rosa Hernandez, F. A., Koger, M., Yohe, L. R., Hedrick, B. P., Davies, K. T. J., Mutumi, G. L., Roseman, C. C., Dumont, E. R., Davalos, L. M., Rossiter, S. J., Sadier*, A. (co-last), & Sears*, K. E. (2023). Cochlea development shapes bat sensory system evolution. The Anatomical Record, 1–12. https://doi.org/10.1002/ar.25353

24. Sadier, A., Anthwal, N., Krause, A.L. et al. Bat teeth illuminate the diversification of mammalian tooth classes. Nat Commun14, 4687 (2023). https://doi.org/10.1038/s41467-023-40158-4
Behind the paper blog post Nature Eco Evo: here and the node: here
Article featured as one of the 50 best papers recently published in an area by Nature communications editors: https://www.nature.com/collections/jadchbbhdi
UW press release and press blog post: here

23. Mutumi GL, Hall RP, Hedrick BP, Yohe LR, Sadier A, Davies KTJ, Rossiter SJ, Sears KE, Dávalos LM, Dumont ER. 2023. Disentangling Mechanical and Sensory Modules in the Radiation of Noctilionoid Bats. The American Naturalist 000–000. https://www.journals.uchicago.edu/doi/full/10.1086/725368

22. Anthwal, N., Urban, D.J., Sadier, A. et al. Insights into the formation and diversification of a novel chiropteran wing membrane from embryonic development. BMC Biol 21, 101 (2023). https://doi.org/10.1186/s12915-023-01598-yhttps://bmcbiol.biomedcentral.com/articles/10.1186/s12915-023-01598-y

21. Yohe LR, Fabbri M, Lee D, Davies KTJ, Yohe TP, Sánchez MKR, Rengifo EM, Hall RP, Mutumi G, Hedrick BP, Sadier A, Simmons NB, Sears KE, Dumont E, Rossiter SJ, Bhullar B-AS, Dávalos LM. n.d. Ecological constraints on highly evolvable olfactory receptor genes and morphology in neotropical bats. Evolution n/a. https://doi.org/10.1111/evo.14591

20. Santana SE*, Grossnickle DM*, Sadier A (co-first)*, Patterson E, Sears KE. 2022. Bat Dentitions: A Model System for Studies at the Interface of Development, Biomechanics, and Evolution. Integrative and Comparative Biology 62:762–73. https://academic.oup.com/icb/article/62/3/762/6586353?login=false

19. Sadier A., Sears, K. and Womack, M. Unravelling the heritage of lost traits, J Exp Part B. https://doi.org/10.1002/jez.b.23030

18. Aidan O Howenstine, Alexa Sadier, Neal Anthwal, Clive LF Lau, Karen E Sears, Non-model systems in mammalian forelimb evo-devo, Current Opinion in Genetics & Development, https://doi.org/10.1016/j.gde.2021.01.012

17. Hall, R.P., Mutumi, G.L., Hedrick, B.P., Yohe, L.R., Sadier, A., Davies, K.T.J., Rossiter, S.J., Sears, K., Dávalos, L.M. and Dumont, E.R. (2021), Find the food first: An omnivorous sensory morphotype predates biomechanical specialization for plant based diets in phyllostomid bats. Evolution https://doi.org/10.1111/evo.14270

16. Nojiri T, Wilson LAB, López-Aguirre C, Tu VT, Kuratani S, Ito K, Higashiyama H, Son NT, Fukui D, Sadier A, Sears KE, Endo H, Kamihori S, Koyabu D. 2021. Embryonic evidence uncovers convergent origins of laryngeal echolocation in bats. Current Biology 31:1353-1365.e3. https://doi.org/10.1016/j.cub.2020.12.043

15. Sadier A, Urban DJ, Anthwal N, Howenstine AO, Sinha I, Sears KE, Sadier A, Urban DJ, Anthwal N, Howenstine AO, Sinha I, Sears KE. 2020. Making a bat: The developmental basis of bat evolution. Genetics and Molecular Biology http://dx.doi.org/10.1590/1678-4685-gmb-2019-0146

14. Sadier A., Santana S., Sears K. The role of core and variable Gene Regulatory Network modules in tooth development and evolution (2020) Integrative and Comparative Biology, icaa116 https://doi.org/10.1093/icb/icaa116

13. Sadier, A., Jackman, W.R., Laudet, V and Gibert, Y. Vertebrate tooth type: is it signaled by a single organizing tooth? (2020) BioEssays 42 (6), 1900229 https://doi.org/10.1002/bies.201900229

12. C Darrin Hulsey, Karly E Cohen, Zerina Johanson, Nidal Karagic, Axel Meyer, Craig T Miller, Alexa Sadier, Adam P Summers, Gareth J Fraser (2020) Grand Challenges in Comparative Tooth Biology Integrative and Comparative Biology icaa038 https://doi.org/10.1093/icb/icaa038

11. Hedrick BP, Mutumi GL, Munteanu VD, Sadier A, Davies KTJ, Rossiter SJ, Sears KE, Dávalos LM, Dumont E. 2020. Morphological Diversification under High Integration in a Hyper Diverse Mammal Clade. J Mammal Evol 27:563–575 https://doi.org/10.1007/s10914-019-09472-x

10. Vial, J., Royet, A., Cassier, P., Tortereau, A., Dinvaut, S., Maillet, D., Gratadou-Hupon, L., Creveaux, M., Sadier, A., Tondeur, G., et al. (2019). The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death. Cell Death Differ 26, 443–454. https://doi.org/10.1038/s41418-018-0128-1

9. Sadier, A., Twarogowska, M., Steklikova, K., Hayden, L., Lambert, A., Schneider, P., Laudet, V., Hovorakova, M., Calvez, V., and Pantalacci, S. (2019). Modeling Edar expression reveals the hidden dynamics of tooth signaling center patterning. PLoS Biol 17, e3000064 https://doi.org/10.1371/journal.pbio.3000064

8. Sears, K., Maier, J.A., Sadier, A., Sorensen, D., and Urban, D.J. (2018). Timing the developmental origins of mammalian limb diversity. Genesis 56. https://doi.org/10.1002/dvg.23079

7. Sadier*, A., Davies*, K.T., Yohe, L.R., Yun, K., Donat, P., Hedrick, B.P., Dumont, E.R., Davalos, L.M., Rossiter, S.J., and Sears, K.E. (2018). Multifactorial processes underlie parallel opsin loss in neotropical bats. Elife 7. https://elifesciences.org/articles/37412

6. Hedrick, B.P., Yohe, L., Vander Linden, A., Davalos, L.M., Sears, K., Sadier, A., Rossiter, S.J., Davies, K.T.J., and Dumont, E. (2018). Assessing Soft-Tissue Shrinkage Estimates in Museum Specimens Imaged With Diffusible Iodine-Based Contrast-Enhanced Computed Tomography (diceCT). Microsc Microanal 24, 284–291. https://doi.org/10.1017/s1431927618000399

5. Urban, D.J., Anthwal, N., Luo, Z.-X., Maier, J.A., Sadier, A., Tucker, A.S., and Sears, K.E. (2017). A new developmental mechanism for the separation of the mammalian middle ear ossicles from the jaw. Proc Biol Sci 284. https://doi.org/10.1098/rspb.2016.2416

4. Gibert, Y., Samarut, E., Pasco-Viel, E., Bernard, L., Borday-Birraux, V., Sadier, A., Labbe, C., Viriot, L., and Laudet, V. (2015). Altered retinoic acid signalling underpins dentition evolution. Proc Biol Sci 282. https://royalsocietypublishing.org/doi/10.1098/rspb.2014.2764

3. Sadier, A., Lambert, E., Chevret, P., Decimo, D., Semon, M., Tohme, M., Ruggiero, F., Ohlmann, T., Pantalacci, S., and Laudet, V. (2015). Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD. BMC Evol Biol 15, 129. https://doi.org/10.1186/s12862-015-0395-0

2. Sadier, A., Viriot, L., Pantalacci, S., and Laudet, V. (2014). The ectodysplasin pathway: from diseases to adaptations. Trends Genet 30, 24–31. https://doi.org/10.1016/j.tig.2013.08.006

1. Pantalacci, S., Chaumot, A., Benoit, G., Sadier, A., Delsuc, F., Douzery, E.J.P., and Laudet, V. (2008). Conserved features and evolutionary shifts of the EDA signaling pathway involved in vertebrate skin appendage development. Mol Biol Evol 25, 912–928. https://doi.org/10.1093/molbev/msn038

Book chapters

Sadier, A., Soukup V. Initiation and periodic patterning of vertebrate dentitions In chapter in “Odontodes: The Developmental and Evolutionary Building Blocks of Dentitions”, in press

Sadier, A. (2019). How Do Gene Networks Promote Morphological Evolution. In Old Questions and Young Approaches to Animal Evolution, J.M. Martín-Durán, and B.C. Vellutini, eds. (Cham: Springer International Publishing), pp. 209–234.

Sadier, A.A. (2016). Regulatory and Coding Changes in Developmental Evolution, Roles of. In Encyclopedia of Evolutionary Biology, R.M. Kliman, ed. (Oxford: Academic Press), pp. 433–440.

AWARDS AND GRANTS

2023 ERC Consolidator - 2.65 million euros

2023 Tremplin ERC - 100000 euros

2023 Bat Biology Foundation – Fieldwork expedition - 3000$

2023 UCLA CSNI ALMS - Imaging - 2000$

2021 Wellcome Trust – Career Development Award – invitation for interview, not awarded

2021 UCLA Chancellor’s award for postdoctoral research 20/21 – awardee

The Chancellor’s Award for Postdoctoral Research recognizes the 10 most important contributions (among the ~1400 postdocs from all disciplines) that postdoctoral scholars make to UCLA’s research mission – 7500$ https://www.postdoc.ucla.edu/chancellors-award-for-postdoctoral-research/

2020 NSF IOS grant - Leader investigator of the project - Collaborators: PIs Karen Sears (UCLA), Sharlene Santana (UW) and Paul François (Mc Gill)

Starting July 2020 – 600 k$

2020 iBiology Young Scientists Seminar Award – winner

2017 MBI workshop travel grant – 600$

2012 Grant ARC (Research against Cancer Association) Foundation

Awarded a project on the role of EDAR in cancer – One year of full support ~20k €

2009 Teaching fellowship – “monitorat”

Extra salary for teaching activities including: TA, full lectures and full courses teaching and conception – 80h/year ~ 7.75k €/year

2009 MRT PhD fellowship

Supporting 3 years of salary for research - Ranked 3/50 (15/50 were awarded) ~12.25k €/year

ACADEMIC ACTIVITIES AND SERVICE

Since 2023: Editorial Board Member, Gene

Since 2021: Editorial Board Member, BMC Eco Evo https://bmcecolevol.biomedcentral.com/

2021: Topic board editor, Diversity journal diversity https://www.mdpi.com/journal/diversity

Since 2019: The Company of Biologists Prelighter, part of the @preLights community - See my prelights here: https://prelights.biologists.com/profiles/aigverte/

Society member: EuroEvoDevo, PanAmEvoDevo, NASBR societies, SDB and BCI (Bat Conservation International), Bat1k genome project, SigmaX, NASA GeneLab

Contact

CV